MND1 Antibody (PACO41550)
- SKU:
- PACO41550
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MND1 Antibody (PACO41550)
The MND1 Antibody (PAC041550) is a valuable tool for researchers studying MND1, a protein involved in meiotic recombination and DNA repair processes. This polyclonal antibody, generated in mice, exhibits high specificity for human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.MND1, also known as meiotic nuclear division protein 1, is essential for proper chromosome segregation during meiosis, ensuring genetic diversity and fertility. Dysregulation of MND1 has been associated with infertility and chromosomal abnormalities, making it a key target for investigation in reproductive biology and genetic disorders.
By targeting MND1 with this antibody, researchers can gain insights into its function and mechanisms of action, paving the way for advancements in fertility treatments, genetic testing, and therapeutic interventions for individuals with meiotic defects. This antibody offers a reliable tool for studying MND1 in both basic research and clinical settings, contributing to our understanding of reproductive health and genetic stability.
| Antibody Name: | MND1 Antibody (PACO41550) |
| Antibody SKU: | PACO41550 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Meiotic nuclear division protein 1 homolog protein (2-205AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: MND1 antibody at 10µg/ml + Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 24 kDa. Observed band size: 24 kDa. |
 | Immunohistochemistry of paraffin-embedded human endometrial cancer using PACO41550 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human gastric cancer using PACO41550 at dilution of 1:100. |
| Background: | Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. |
| Synonyms: | Meiotic nuclear division protein 1 homolog, MND1, GAJ |
| UniProt Protein Function: | MND1: Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Stimulates both DMC1- and RAD51-mediated homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. Belongs to the MND1 family. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 4q31.3 Cellular Component: nucleus Molecular Function:DNA binding Biological Process: meiotic cell cycle; DNA recombination |
| NCBI Summary: | The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9BWT6 |
| NCBI GenInfo Identifier: | 74733462 |
| NCBI Gene ID: | 84057 |
| NCBI Accession: | Q9BWT6.1 |
| UniProt Secondary Accession: | Q9BWT6,B2R5F9, |
| UniProt Related Accession: | Q9BWT6 |
| Molecular Weight: | 205 |
| NCBI Full Name: | Meiotic nuclear division protein 1 homolog |
| NCBI Synonym Full Names: | meiotic nuclear divisions 1 homolog (S. cerevisiae) |
| NCBI Official Symbol: | MND1Â Â |
| NCBI Official Synonym Symbols: | GAJÂ Â |
| NCBI Protein Information: | meiotic nuclear division protein 1 homolog; MND1; homolog of yeast MND1 |
| UniProt Protein Name: | Meiotic nuclear division protein 1 homolog |
| Protein Family: | MND1-interacting protein |
| UniProt Gene Name: | MND1Â Â |
| UniProt Entry Name: | MND1_HUMAN |
| Antibodies |
| MND1 Antibody (PACO10533) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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