The MN1 Monoclonal Antibody is a powerful tool for researchers studying the MN1 protein, a transcriptional co-activator known to be involved in hematopoiesis and leukemia. This antibody, produced through hybridoma technology, shows high specificity and sensitivity for detecting MN1 in both human and mouse samples, making it a versatile tool for various research applications.MN1 is a critical regulator of gene expression and cell proliferation, making it a key player in normal hematopoiesis and leukemia development. By targeting MN1, researchers can gain valuable insights into the molecular mechanisms underlying these processes and potentially identify new therapeutic targets for leukemia treatments.
With its superior performance in techniques such as Western blot and immunohistochemistry, the MN1 Monoclonal Antibody enables precise and reliable detection of MN1 in different cell types and tissues. This makes it an essential asset for studies focused on understanding the role of MN1 in hematopoiesis, leukemia, and other related fields of research.
Antibody Name:
MN1 Antibody (PACO21834)
Antibody SKU:
PACO21834
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human MN1.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from COLO cells, using MN1 antibody.
Background:
May play a role in tumor suppression. The MGC Project Team, Genome Res. 14:2121-2127(2004).
Synonyms:
Probable tumor suppressor protein MN1; MN1;
UniProt Protein Function:
MN1: May play a role in tumor suppression. A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL. Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.
UniProt Protein Details:
Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Tumor suppressor
Chromosomal Location of Human Ortholog: 22q12.1
Disease: Meningioma, Familial, Susceptibility To
NCBI Summary:
Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]
