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MN1 Antibody (PACO01075)

SKU:
PACO01075
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269
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Description

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MN1 Antibody (PACO01075)

The MN1 Polyclonal Antibody (PACO01075) is a valuable tool for researchers studying MN1, a transcription coactivator involved in hematopoietic development and leukemia. This antibody, produced in rabbits, exhibits high reactivity with human samples and is optimized for Western blot applications. By binding specifically to the MN1 protein, researchers can accurately detect and analyze its expression in various cell types, making it an essential component for studies in hematology and cancer research.

MN1 is a critical player in transcriptional regulation and is known to be dysregulated in leukemia, where it contributes to abnormal cell proliferation and differentiation. Understanding the role of MN1 in these processes is key to developing targeted therapies for leukemia and other hematologic disorders. The MN1 Polyclonal Antibody is a reliable tool for researchers aiming to unravel the complex mechanisms underlying MN1 function and its implications in disease pathology.

Antibody Name:MN1 Antibody
Antibody SKU:PACO01075
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:WB:1:500-1:2000
Species Reactivity:Human
Immunogen:synthesized peptide derived from the Internal region of human MN1.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:MN1; Probable tumor suppressor protein MN1
UniProt Protein Function:MN1: May play a role in tumor suppression. A chromosomal aberration involving MN1 may be a cause of acute myeloid leukemia (AML). Translocation t(12;22)(p13;q11) with TEL. Defects in MN1 involved in the development of meningiomas, slowly growing benign tumors derived from the arachnoidal cap cells of the leptomeninges, the soft coverings of the brain and spinal cord. Meningiomas are believed to be the most common primary tumors of the central nervous system in man.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator; Tumor suppressor

Chromosomal Location of Human Ortholog: 22q12.1

Disease: Meningioma, Familial, Susceptibility To

NCBI Summary:Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]
UniProt Code:Q10571
NCBI GenInfo Identifier:215274133
NCBI Gene ID:4330
NCBI Accession:Q10571.3
UniProt Secondary Accession:Q10571,A9Z1V9,
UniProt Related Accession:Q10571
Molecular Weight:136,001 Da
NCBI Full Name:Transcriptional activator MN1
NCBI Synonym Full Names:MN1 proto-oncogene, transcriptional regulator
NCBI Official Symbol:MN1  
NCBI Official Synonym Symbols:MGCR; MGCR1; MGCR1-PEN; dJ353E16.2  
NCBI Protein Information:transcriptional activator MN1
UniProt Protein Name:Transcriptional activator MN1
UniProt Synonym Protein Names:Probable tumor suppressor protein MN1Curated
Protein Family:Transcriptional activator
UniProt Gene Name:MN1  
UniProt Entry Name:MN1_HUMAN

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