The MMP9 Polyclonal Antibody (CAB11521) is a valuable tool for researchers studying matrix metalloproteinase 9 (MMP9), an enzyme involved in extracellular matrix remodeling and tissue repair processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to MMP9, this antibody enables precise detection and analysis of MMP9 expression in a variety of cell types, making it ideal for investigations in fields such as inflammation, wound healing, and cancer research.
MMP9 plays a crucial role in tissue remodeling, inflammation, and cancer progression, making it a key target for therapeutic interventions in conditions such as arthritis, cardiovascular diseases, and cancer metastasis. By elucidating the functions and regulation of MMP9, researchers can gain insights into the mechanisms underlying these pathologies and potentially identify novel approaches for treatment and prevention. The MMP9 Polyclonal Antibody is a valuable tool for advancing our understanding of MMP9 biology and its implications for human health.
Product Name:
MMP9 Rabbit Polyclonal Antibody
SKU:
CAB11521
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 401-500 of human MMP9 (NP_004985.2).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.
Purification Method:
Affinity purification
Gene ID:
4318
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded mouse heart using MMP9 Rabbit pAb (CAB11521) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
