The MMP8 Polyclonal Antibody (CAB1963) is a powerful research tool designed for studying Matrix Metalloproteinase 8 (MMP8), an enzyme involved in tissue remodeling and inflammation. This antibody, generated in rabbits, exhibits high reactivity specifically with human samples, making it ideal for use in Western blot applications. By binding to MMP8, researchers can accurately detect and analyze the enzyme in various cell types, offering valuable insights into its function and role in diseases such as cancer and inflammatory conditions.
MMP8, also known as neutrophil collagenase, plays a critical role in the breakdown of extracellular matrix proteins and regulation of inflammatory processes. Dysregulation of MMP8 activity has been implicated in various pathological conditions, making it a promising target for therapeutic interventions. By studying MMP8 using this polyclonal antibody, researchers can further elucidate its involvement in disease progression and potentially develop novel treatment strategies aimed at modulating its activity.
Product Name:
MMP8 Rabbit Polyclonal Antibody
SKU:
CAB1963
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 101-467 of human MMP8 (NP_002415.1).
This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
4317
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using MMP8 Rabbit pAb (CAB1963) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
