Mmp3 Antibody (PACO33840)
- SKU:
- PACO33840
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Mmp3 Antibody (PACO33840)
The MMP3 Polyclonal Antibody (PACO33840) is a vital tool for researchers studying matrix metalloproteinase 3 (MMP3), an enzyme associated with tissue remodeling and extracellular matrix degradation. This antibody, derived from rabbit immunization, exhibits strong reactivity towards human MMP3, making it suitable for Western blot applications. By binding specifically to MMP3 protein, this antibody enables precise detection and analysis in a variety of cell types, making it indispensable for studies in fields such as cancer research and tissue engineering.
MMP3, also known as stromelysin-1, plays a crucial role in the breakdown of extracellular matrix components, contributing to physiological processes such as wound healing, embryo development, and tissue repair. Dysregulation of MMP3 activity has been linked to pathological conditions including cancer invasion and metastasis, arthritis, and cardiovascular diseases. By elucidating the functions of MMP3, researchers can uncover potential therapeutic targets for diseases characterized by aberrant extracellular matrix remodeling.
| Antibody Name: | Mmp3 Antibody (PACO33840) |
| Antibody SKU: | PACO33840 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000 |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Stromelysin-1 protein (104-477AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO33840 diluted at 1:709 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | Western Blot Positive WB detected in: Mouse liver tissue, Mouse kidney tissue All lanes: Mmp3 antibody at 2.8µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 54 kDa Observed band size: 54 kDa . |
| Background: | Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. |
| Synonyms: | Stromelysin-1 (SL-1) (EC 3.4.24.17) (EMS-2) (Matrix metalloproteinase-3) (MMP-3) (Transin-1), Mmp3 |
| UniProt Protein Function: | MMP3: Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. Defects in MMP3 are the cause of susceptibility to coronary heart disease type 6 (CHDS6). A multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Decreased capacity of the coronary vessels is often associated with thickening and loss of elasticity of the coronary arteries. A polymorphism in the MMP3 promoter region is associated with the risk of coronary heart disease and myocardial infarction, due to lower MMP3 proteolytic activity and higher extracellular matrix deposition in atherosclerotic lesions. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted; Protease; Secreted, signal peptide; EC 3.4.24.17 Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; protein complex; mitochondrion; dendrite; extracellular region; cytosol; nucleus Molecular Function:peptidase activity; hydrolase activity; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; metal ion binding; endopeptidase activity; protein complex binding; calcium ion binding Biological Process: positive regulation of protein oligomerization; collagen catabolic process; negative regulation of protein kinase B signaling cascade; protein catabolic process; proteolysis; regulation of cell migration; positive regulation of cell migration |
| NCBI Summary: | This gene encodes a member of the matrix metalloproteinase family of extracellular matrix-degrading enzymes that is involved in tissue remodeling, wound repair, progression of atherosclerosis and tumor invasion. The encoded protein is activated by the removal of an N-temrinal activation peptide to generate a zinc-dependent endopeptidase with a broad range of substrates such as proteoglycans, laminin, fibronectin, elastin, and collagens. This gene is located in a cluster of other matrix metalloproteinase genes on chromosome 9. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P28862 |
| NCBI GenInfo Identifier: | 461769 |
| NCBI Gene ID: | 17392 |
| NCBI Accession: | P28862.2 |
| UniProt Related Accession: | P28862 |
| Molecular Weight: | 53,845 Da |
| NCBI Full Name: | Stromelysin-1 |
| NCBI Synonym Full Names: | matrix metallopeptidase 3 |
| NCBI Official Symbol: | Mmp3Â Â |
| NCBI Official Synonym Symbols: | SLN1; Str1; SLN-1; STR-1; Stmy1Â Â |
| NCBI Protein Information: | stromelysin-1; SL-1; EMS-2; MMP-3; transin-1; progelatinase; stromelysin 1; matrix metalloproteinase 3; matrix metalloproteinase-3 |
| UniProt Protein Name: | Stromelysin-1 |
| UniProt Synonym Protein Names: | EMS-2; Matrix metalloproteinase-3; MMP-3; Transin-1 |
| Protein Family: | Stromelysin |
| UniProt Gene Name: | Mmp3Â Â |
| UniProt Entry Name: | MMP3_MOUSE |
| ELISA Kits |
| Mouse MMP-3 (Matrix Metalloproteinase 3) CLIA Kit (MOES00333) |
| Mouse Stromelysin-1 (Mmp3) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
MMP3 Rabbit Polyclonal Antibody (CAB1202)
Rabbit MMP3 ELISA Kit
Rat MMP3 ELISA Kit
Porcine MMP3 ELISA Kit
Mouse MMP3 ELISA Kit
Mouse Stromelysin-1 (Mmp3) ELISA Kit (MOEB0095)
