MMP28 Antibody (PACO14715)
- SKU:
- PACO14715
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MMP28 Antibody (PACO14715)
The MMP28 Polyclonal Antibody (PACO14715) is a valuable tool for researchers studying matrix metalloproteinase 28 (MMP28), a member of the matrix metalloproteinase family involved in extracellular matrix remodeling. This antibody, generated in rabbits, exhibits high reactivity with human samples and is suitable for use in Western blot applications. By targeting the MMP28 protein, this antibody allows for the detection and analysis of MMP28 expression in various cell types, making it an essential component in studies related to tissue remodeling, wound healing, and cancer progression.MMP28 is known for its role in degrading extracellular matrix components, promoting cell migration, and facilitating tissue remodeling processes.
Dysregulation of MMP28 expression has been linked to various diseases, including cancer, arthritis, and cardiovascular disorders. By studying the function and regulation of MMP28, researchers can gain valuable insights into disease mechanisms and potentially identify new therapeutic targets for intervention. The MMP28 Polyclonal Antibody is a valuable tool for advancing our understanding of MMP28 biology and its implications in health and disease.
| Antibody Name: | MMP28 Antibody (PACO14715) |
| Antibody SKU: | PACO14715 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Fusion protein of human MMP28 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: Mouse heart tissue, Primary antibody: PACO14715(MMP28 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO14715(MMP28 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Transcript variants encoding different isoforms have been described. |
| Synonyms: | matrix metallopeptidase 28 |
| UniProt Protein Function: | MMP28: Can degrade casein. Could play a role in tissues homeostasis and repair. Belongs to the peptidase M10A family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Protease; EC 3.4.24.-; Secreted; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 17q12 Cellular Component: proteinaceous extracellular matrix; cytoplasm Molecular Function:zinc ion binding; metalloendopeptidase activity; calcium ion binding Biological Process: proteolysis |
| NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014] |
| UniProt Code: | Q9H239 |
| NCBI GenInfo Identifier: | 37538314 |
| NCBI Gene ID: | 79148 |
| NCBI Accession: | Q9H239.2 |
| UniProt Secondary Accession: | Q9H239,Q96F04, Q96TE2, |
| UniProt Related Accession: | Q9H239 |
| Molecular Weight: | 520 |
| NCBI Full Name: | Matrix metalloproteinase-28 |
| NCBI Synonym Full Names: | matrix metallopeptidase 28 |
| NCBI Official Symbol: | MMP28Â Â |
| NCBI Official Synonym Symbols: | MM28; MMP25; MMP-25; MMP-28; EPILYSINÂ Â |
| NCBI Protein Information: | matrix metalloproteinase-28; matrix metalloprotease MMP25 |
| UniProt Protein Name: | Matrix metalloproteinase-28 |
| UniProt Synonym Protein Names: | Epilysin |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | MMP28Â Â |
| UniProt Entry Name: | MMP28_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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