MMP27 Antibody (PACO18243)
- SKU:
- PACO18243
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
MMP27 Antibody (PACO18243)
The MMP27 Polyclonal Antibody (PAC018243) is a valuable tool for researchers studying matrix metalloproteinase 27 (MMP27), an enzyme involved in extracellular matrix degradation and tissue remodeling. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications.MMP27 is known to play a role in various biological processes, including cell migration, angiogenesis, and tissue repair. Dysregulation of MMP27 has been implicated in pathological conditions such as cancer metastasis and fibrotic diseases. By targeting MMP27 with this antibody, researchers can investigate its expression and activity in different cell types, providing insights into its functions in both normal and disease states.
With its specificity and sensitivity, the MMP27 Polyclonal Antibody is a valuable tool for studying MMP27 biology in the fields of oncology, wound healing, and tissue remodeling. By enabling the detection and analysis of MMP27 protein levels, this antibody contributes to a better understanding of its role in health and disease, paving the way for potential therapeutic interventions targeting MMP27.
| Antibody Name: | MMP27 Antibody (PACO18243) |
| Antibody SKU: | PACO18243 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human MMP27 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18243(MMP27 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO18243(MMP27 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. |
| Synonyms: | Matrix metallopeptidase 27 |
| UniProt Protein Function: | MMP27: Matrix metalloproteinases degrade protein components of the extracellular matrix such as fibronectin, laminin, gelatins and/or collagens. Belongs to the peptidase M10A family. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Secreted; Secreted, signal peptide; Protease Chromosomal Location of Human Ortholog: 11q24 Cellular Component: extracellular matrix Molecular Function:zinc ion binding; metalloendopeptidase activity; calcium ion binding Biological Process: collagen catabolic process; proteolysis |
| NCBI Summary: | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9H306 |
| NCBI GenInfo Identifier: | 296437372 |
| NCBI Gene ID: | 64066 |
| NCBI Accession: | Q9H306.2 |
| UniProt Secondary Accession: | Q9H306,Q6UWK6, |
| UniProt Related Accession: | Q9H306 |
| Molecular Weight: | 513 |
| NCBI Full Name: | Matrix metalloproteinase-27 |
| NCBI Synonym Full Names: | matrix metallopeptidase 27 |
| NCBI Official Symbol: | MMP27Â Â |
| NCBI Official Synonym Symbols: | MMP-27Â Â |
| NCBI Protein Information: | matrix metalloproteinase-27; matrix metalloprotease 27; matrix metalloproteinase 27 |
| UniProt Protein Name: | Matrix metalloproteinase-27 |
| Protein Family: | Matrix metalloproteinase |
| UniProt Gene Name: | MMP27Â Â |
| UniProt Entry Name: | MMP27_HUMAN |
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