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MMP25 Rabbit Polyclonal Antibody (CAB3032)

SKU:
CAB3032
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
  • Cell Biology Antibodies 8 Anti-MMP25 Antibody CAB3032
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  • Cell Biology Antibodies 8 Anti-MMP25 Antibody CAB3032
  • Cell Biology Antibodies 8 Anti-MMP25 Antibody CAB3032
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:MMP25 Rabbit Polyclonal Antibody
SKU:CAB3032
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-540 of human MMP25 (NP_071913.1).
Sequence:SPRP ARLH RFWE GLPA QVRV VQAA YARH RDGR ILLF SGPQ FWVF QDRQ LEGG ARPL TELG LPPG EEVD AVFS WPQN GKTY LVRG RQYW RYDE AAAR PDPG YPRD LSLW EGAP PSPD DVTV SNAG DTYF FKGA HYWR FPKN SIKT EPDA PQPM GPNW LDCP APSS GPRA PRPP KATP VSET CDCQ CELN QAA
Tested Applications:WB IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200
Synonyms:MMP20; MMPL1; MMP-25; MMP20A; MT6MMP; MTMMP6; MT-MMP6; MT6-MMP; MT-MMP 6; MMP25
Positive Sample:K-562,BT-474
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Secreted, extracellular matrix, extracellular space.
Calculated MW:63kDa
Observed MW:70kDa

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.

Purification Method:Affinity purification
Gene ID:64386
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of extracts of various cell lines, using MMP25 antibody (CAB3032) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.

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