The MMP25 Polyclonal Antibody (CAB3032) is a powerful tool for researchers studying matrix metalloproteinase 25 (MMP25), a key enzyme involved in extracellular matrix degradation and tissue remodeling. This antibody, produced in rabbits, exhibits high reactivity with human samples and is specifically validated for use in Western blot applications. By targeting the MMP25 protein, researchers can effectively detect and analyze MMP25 expression in various cell types, providing valuable insights into its role in processes such as tumor metastasis and tissue repair.
MMP25, also known as MT6-MMP, is a member of the matrix metalloproteinase family that is implicated in cancer progression, inflammation, and tissue regeneration. Its unique functions and regulatory mechanisms make it a promising target for investigating the pathogenesis of cancer and other diseases involving abnormal tissue remodeling. By utilizing the MMP25 Polyclonal Antibody, researchers can further dissect the molecular mechanisms underlying MMP25 activity and explore its therapeutic potential in various medical conditions.
Product Name:
MMP25 Rabbit Polyclonal Antibody
SKU:
CAB3032
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 350-540 of human MMP25 (NP_071913.1).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
Purification Method:
Affinity purification
Gene ID:
64386
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MMP25 antibody (CAB3032) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
