MMP25 Rabbit Polyclonal Antibody (CAB15886)
- SKU:
- CAB15886
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Product Name: | MMP25 Rabbit Polyclonal Antibody |
| SKU: | CAB15886 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 321-539 of human MMP25 (NP_071913.1). |
| Sequence: | FDAI ANIR GETF FFKG PWFW RLQP SGQL VSPR PARL HRFW EGLP AQVR VVQA AYAR HRDG RILL FSGP QFWV FQDR QLEG GARP LTEL GLPP GEEV DAVF SWPQ NGKT YLVR GRQY WRYD EAAA RPDP GYPR DLSL WEGA PPSP DDVT VSNA GDTY FFKG AHYW RFPK NSIK TEPD APQP MGPN WLDC PAPS SGPR APRP PKAT PVSE TCDC QCEL NQA |
| Tested Applications: | WB IHC-P IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
| Synonyms: | MMP20; MMPL1; MMP-25; MMP20A; MT6MMP; MTMMP6; MT-MMP6; MT6-MMP; MT-MMP 6; MMP25 |
| Positive Sample: | A-549,HT-29,Mouse lung,Mouse liver,Rat liver |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Secreted, extracellular matrix, extracellular space. |
| Calculated MW: | 63kDa |
| Observed MW: | 75kDa |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
| Purification Method: | Affinity purification |
| Gene ID: | 64386 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates using MMP25 Rabbit pAb (CAB15886) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s. |
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