The MMP25 Polyclonal Antibody (CAB15886) is an essential tool for researchers studying Matrix Metalloproteinase 25, a key enzyme involved in extracellular matrix degradation, tissue remodeling, and cell migration. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting MMP25 in human samples, making it a valuable asset for various experimental applications.Matrix Metalloproteinase 25, a member of the matrix metalloproteinase family, is known for its role in cancer progression, tissue remodeling in various physiological processes, and inflammatory responses.
By targeting MMP25 with this polyclonal antibody, researchers can enhance their understanding of its functions and mechanisms in disease pathogenesis, particularly in cancer biology and inflammatory conditions.With its validated performance in Western blot assays, the MMP25 Polyclonal Antibody enables accurate quantification and analysis of MMP25 expression in different cell types and tissues. This antibody is a crucial tool for exploring the potential therapeutic implications of targeting MMP25 in cancer treatment strategies and other disease interventions.
Product Name:
MMP25 Rabbit Polyclonal Antibody
SKU:
CAB15886
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 321-539 of human MMP25 (NP_071913.1).
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25.
Purification Method:
Affinity purification
Gene ID:
64386
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MMP25 Rabbit pAb (CAB15886) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
