The MMP24 Polyclonal Antibody (PACO18239) is a crucial tool for researchers studying matrix metalloproteinase 24 (MMP24), an enzyme involved in extracellular matrix remodeling and tissue homeostasis. This antibody, produced in rabbits, is highly specific to human MMP24 samples and has been validated for use in Western blot applications.MMP24 plays a key role in various physiological processes, including tissue development, wound healing, and inflammation. Dysregulation of MMP24 activity has been implicated in several pathological conditions, such as cancer metastasis and neurological disorders.
The MMP24 Polyclonal Antibody enables precise detection of MMP24 protein levels in different cell types, allowing researchers to investigate its role in disease progression and explore potential therapeutic interventions.By utilizing the MMP24 Polyclonal Antibody in their research, scientists can gain a deeper understanding of the molecular mechanisms underlying MMP24 function and its impact on disease pathology. This antibody serves as a valuable tool for studies in oncology, neurology, and other fields where MMP24-mediated processes play a significant role.
Antibody Name:
MMP24 Antibody (PACO18239)
Antibody SKU:
PACO18239
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human MMP24
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using PACO18239(MMP24 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases.
Synonyms:
matrix metallopeptidase 24 (membrane-inserted)
UniProt Protein Function:
MMP24: Activates progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. Belongs to the peptidase M10A family.
UniProt Protein Details:
Protein type:Membrane protein, integral; EC 3.4.24.-; Activator; Protease
Chromosomal Location of Human Ortholog: 20q11.2
Cellular Component: proteinaceous extracellular matrix; integral to plasma membrane; trans-Golgi network membrane
Molecular Function:zinc ion binding; cadherin binding; metalloendopeptidase activity; enzyme activator activity; calcium ion binding
Biological Process: positive regulation of catalytic activity; glial cell differentiation; proteolysis; detection of temperature stimulus involved in sensory perception of pain
NCBI Summary:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]
