MMP2 Rabbit Polyclonal Antibody (CAB6247)
- SKU:
- CAB6247
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
Product Name: | MMP2 Rabbit Polyclonal Antibody |
SKU: | CAB6247 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 451-660 of human MMP2 (NP_004521.1). |
Sequence: | IDLG TGPT PTLG PVTP EICK QDIV FDGI AQIR GEIF FFKD RFIW RTVT PRDK PMGP LLVA TFWP ELPE KIDA VYEA PQEE KAVF FAGN EYWI YSAS TLER GYPK PLTS LGLP PDVQ RVDA AFNW SKNK KTYI FAGD KFWR YNEV KKKM DPGF PKLI ADAW NAIP DNLD AVVD LQGG GHSY FFKG AYYL KLEN QSLK SVKF GSIK SDWL GC |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II; MMP2 |
Positive Sample: | U-87 MG,C2C12,Mouse heart,Rat lung |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Membrane, Mitochondrion, Nucleus, Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 74kDa |
Observed MW: | 64kDa/72kDa |
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 4313 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |