The MMP2 Polyclonal Antibody (CAB6247) is a valuable tool for researchers studying Matrix Metalloproteinase 2 (MMP2), an important enzyme involved in tissue remodeling and degradation. This antibody, produced in rabbits, is highly specific to human MMP2 and has been validated for use in Western blot applications. By binding to MMP2, this antibody allows for the detection and analysis of MMP2 protein levels in various cell types, making it ideal for studies in cancer, cardiovascular diseases, and wound healing research.
MMP2 is a key player in extracellular matrix remodeling and has been implicated in various pathological conditions such as tumor invasion and metastasis. By understanding the role of MMP2 in these processes, researchers can develop targeted therapies to inhibit its activity in disease states. The MMP2 Polyclonal Antibody is a valuable tool for investigating the function of MMP2 in health and disease, ultimately contributing to the development of novel treatments for conditions influenced by MMP2 activity.
Product Name:
MMP2 Rabbit Polyclonal Antibody
SKU:
CAB6247
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 451-660 of human MMP2 (NP_004521.1).
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4313
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MMP2 Rabbit pAb (CAB6247) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
