The MMP2 Polyclonal Antibody (CAB11144) is a powerful tool for researchers studying matrix metalloproteinase 2 (MMP2), an important enzyme involved in tissue remodeling and metastasis in various diseases, including cancer. This antibody, raised in rabbits, specifically targets and binds to the MMP2 protein, allowing for accurate detection and analysis in a variety of cell types.MMP2 is known for its role in cancer progression, as it facilitates the degradation of extracellular matrix components, helping cancer cells invade surrounding tissues and spread to other parts of the body. By targeting MMP2 with this antibody, researchers can gain valuable insights into its activity and potential therapeutic strategies for inhibiting its function in cancer and other diseases.
This MMP2 Polyclonal Antibody is validated for use in Western blot applications and is highly reactive with human samples, making it a versatile tool for studies in oncology, cell biology, and tissue engineering. Its ability to specifically detect MMP2 makes it a valuable asset for research aimed at understanding the mechanisms of disease progression and developing targeted therapies to improve patient outcomes.
Product Name:
MMP2 Rabbit Polyclonal Antibody
SKU:
CAB11144
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human MMP2 (NP_004521.1).
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
4313
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MMP2 Rabbit pAb (CAB11144) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
