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MMP2 Monoclonal Antibody (CAB23496)

SKU:
CAB23496
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IF
$167 - $635
Frequently bought together:

Description

MMP2 Monoclonal Antibody (CAB23496)

The MMP2 Monoclonal Antibody is a valuable tool for researchers studying matrix metalloproteinase 2, an enzyme involved in tissue remodeling and cell migration. This antibody, produced through hybridoma technology, specifically recognizes MMP2 and has been validated for use in various applications, including Western blot and immunohistochemistry.MMP2 is known to play a critical role in cancer metastasis, cardiovascular diseases, and inflammatory conditions. By using the MMP2 Monoclonal Antibody, researchers can accurately detect and analyze MMP2 expression in different cell types and tissues, providing valuable insights into its function and potential therapeutic targets in these disease contexts.

With its high specificity and sensitivity, the MMP2 Monoclonal Antibody is an essential tool for investigating the role of MMP2 in various physiological and pathological processes, making it a valuable addition to any research laboratory focused on understanding the complex mechanisms of tissue remodeling and cell migration.

Product Name:MMP2 Monoclonal Antibody
Product Code:CAB23496
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Clone No:ARC57602
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting, Immunofluorescence
Recommended Dilution:WB 1:500-1:1000, IF/ICC 1:50-1:200
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3.
Positive Samples:U-87MG, C2C12, Rat lung
Cellular Location:Cytoplasm, Membrane, Mitochondrion, Nucleus, Secreted, extracellular matrix, extracellular space

This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 451-660 of human MMP2(NP_004521.1).
Sequence:ATTGA CCTTG GCACC GGCCC CACCC CCACG CTGGG CCCTG TCACT CCTGA GATCT GCAAA CAGGA CATTG TATTT GATGG CATCG CTCAG ATCCG TGGTG AGATC TTCTT CTTCA AGGAC CGGTT CATTT GGCGG ACTGT GACGC CACGT GACAA GCCCA TGGGG CCCCT GCTGG TGGCC ACATT CTGGC CTGAG CTCCC GGAAA AGATT GATGC GGTAT ACGAG GCCCC ACAGG AGGAG AAGGC TGTGT TCTTT GCAGG GAATG AATAC TGGAT CTACT CAGCC AGCAC CCTGG AGCGA GGGTA CCCCA AGCCA CTGAC CAGCC TGGGA CTGCC CCCTG ATGTC CAGCG AGTGG ATGCC GCCTT TAACT GGAGC AAAAA CAAGA AGACA TACAT CTTTG CTGGA GACAA ATTCT GGAGA TACAA TGAGG TGAAG AAGAA AATGG ATCCT GGCTT CCCCA AGCTC ATCGC AGATG CCTGG AATGC CATCC CCGAT AACCT GGATG CCGTC GTGGA CCTGC AGGGC GGCGG TCACA GCTAC TTCTT CAAGG GTGCC TATTA CCTGA AGCTG GAGAA CCAAA GTCTG AAGAG CGTGA AGTTT GGAAG CATCA AATCC GACTG GCTAG GCTGC
Synonyms:CLG4
Calculated MW:74kDa
Observed MW:64kDa/72kDa

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