The MMP2 Polyclonal Antibody (PAC02894) is a valuable tool for researchers studying matrix metalloproteinase 2 (MMP2), a key enzyme involved in extracellular matrix degradation and tissue remodeling. Raised in rabbits, this antibody is highly specific to human samples and has been validated for use in Western blot applications. MMP2 plays a crucial role in processes such as wound healing, angiogenesis, and tissue remodeling, making it a target of interest in various fields including cancer research and cardiovascular disease.
The MMP2 Polyclonal Antibody binds specifically to MMP2, allowing for accurate detection and analysis in a variety of cell types. By studying MMP2 expression and activity, researchers can gain insights into its role in disease progression and potential therapeutic targets. The MMP2 Polyclonal Antibody is a valuable tool for advancing research in areas such as cancer metastasis, tissue fibrosis, and vascular remodeling.
Antibody Name:
Mmp2 Antibody (PACO28294)
Antibody SKU:
PACO28294
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Rat
Immunogen:
Recombinant Rat 72 kDa type IV collagenase protein (110-662AA)
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- |-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3β in vitro. Involved in the formation of the fibrovascular tissues (By similarity).
Synonyms:
72 kDa type IV collagenase (EC 3.4.24.24) (72 kDa gelatinase) (Gelatinase A) (Matrix metalloproteinase-2) (MMP-2) [Cleaved into: PEX], Mmp2
UniProt Protein Function:
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues.
NCBI Summary:
plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD, Feb 2006]
