MMP2 Rabbit Polyclonal Antibody (CAB11144)
- SKU:
- CAB11144
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cardiovascular
Description
| Product Name: | MMP2 Rabbit Polyclonal Antibody |
| SKU: | CAB11144 |
| Size: | 20uL, 100uL |
| Isotype: | IgG |
| Host Species: | Rabbit |
| Reactivity: | Human,Mouse,Rat |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human MMP2 (NP_004521.1). |
| Sequence: | DVAP KTDK ELAV QYLN TFYG CPKE SCNL FVLK DTLK KMQK FFGL PQTG DLDQ NTIE TMRK PRCG NPDV ANYN FFPR KPKW DKNQ ITYR IIGY TPDL DPET VDDA FARA FQVW SDVT PLRF SRIH DGEA DIMI NFGR WEHG DGYP FDGK DGLL AHAF APGT GVGG DSHF DDDE LWTL GEGQ VVRV KYGN ADGE YCKF PFLF NGKE YNSC TDTG RSDG FLWC STTY NFEK DGKY GFCP HEAL F |
| Tested Applications: | WB IF/ICC ELISA |
| Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
| Synonyms: | CLG4; MONA; CLG4A; MMP-2; TBE-1; MMP-II; MMP2 |
| Positive Sample: | Mouse lung.Rat lung |
| Conjugate: | Unconjugated |
| Cellular Localization: | Cytoplasm, Membrane, Mitochondrion, Nucleus, Secreted, extracellular matrix, extracellular space. |
| Calculated MW: | 74kDa |
| Observed MW: | 72kDa |
This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Purification Method: | Affinity purification |
| Gene ID: | 4313 |
| Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |
 | Western blot analysis of various lysates, using MMP2 Rabbit pAb (CAB11144) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s. |
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