MMP17 Rabbit Polyclonal Antibody (CAB3030)
- SKU:
- CAB3030
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | MMP17 Rabbit Polyclonal Antibody |
SKU: | CAB3030 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 265-565 of human MMP17 (NP_057239.4). |
Sequence: | IMRP YYQG PVGD PLRY GLPY EDKV RVWQ LYGV RESV SPTA QPEE PPLL PEPP DNRS SAPP RKDV PHRC STHF DAVA QIRG EAFF FKGK YFWR LTRD RHLV SLQP AQMH RFWR GLPL HLDS VDAV YERT SDHK IVFF KGDR YWVF KDNN VEEG YPRP VSDF SLPP GGID AAFS WAHN DRTY FFKD QLYW RYDD HTRH MDPG YPAQ SPLW RGVP STLD DAMR WSDG ASYF FRGQ EYWK VLDG ELEV APGY PQST ARDW LVCG DSQA DGSV AAGV DAAE GPRA PPGQ HDQS RSED GYEV CSCT S |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | MMP-17; MT4MMP; MTMMP4; MT4-MMP; MMP17 |
Positive Sample: | SW480,RAW264.7,Mouse testis,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Extracellular side, GPI-anchor, Lipid-anchor, Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 67kDa |
Observed MW: | 75kDa |
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers.
Purification Method: | Affinity purification |
Gene ID: | 4326 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |