The MMP17 Polyclonal Antibody (CAB3030) is specifically designed for research focused on Matrix Metalloproteinase 17 (MMP17), a member of the matrix metalloproteinase (MMP) family of proteins involved in tissue remodeling and degradation. The antibody, produced in rabbits, is highly reactive with human samples and is suitable for use in Western blot applications. It recognizes and binds to MMP17, facilitating its detection and analysis in a variety of cell types.MMP17 is known to play a role in the breakdown of extracellular matrix components, such as collagen, and is implicated in processes like wound healing, tissue repair, and tumor progression.
Its dysregulation has been linked to various pathological conditions, including cancer metastasis, arthritis, and cardiovascular diseases. Studying the functions and mechanisms of MMP17 can provide valuable insights into these disease processes and potentially lead to the development of novel therapeutic interventions targeting MMP17 activity.This MMP17 Polyclonal Antibody is a valuable tool for researchers investigating the role of MMP17 in health and disease, offering reliable and specific detection capabilities that can help advance our understanding of the protein's biology and potential clinical implications.
Product Name:
MMP17 Rabbit Polyclonal Antibody
SKU:
CAB3030
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 265-565 of human MMP17 (NP_057239.4).
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein is unique among the membrane-type matrix metalloproteinases in that it is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) anchor. Elevated expression of the encoded protein has been observed in osteoarthritis and multiple human cancers.
Purification Method:
Affinity purification
Gene ID:
4326
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MMP17 Rabbit pAb (CAB3030) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
