The MMP15 Polyclonal Antibody (PACO14711) is a valuable tool for researchers studying matrix metalloproteinase 15 (MMP15), a key enzyme involved in extracellular matrix degradation and tissue remodeling. This antibody, generated in rabbits, has high specificity and sensitivity for detecting MMP15 in human samples, making it ideal for use in Western blotting and immunohistochemistry experiments.MMP15 plays a crucial role in processes such as wound healing, angiogenesis, and tumor metastasis by breaking down components of the extracellular matrix.
Dysregulation of MMP15 activity has been linked to various pathological conditions, including cancer and fibrosis, making it a promising therapeutic target for drug development.By using the MMP15 Polyclonal Antibody, researchers can gain valuable insights into the role of MMP15 in normal physiological processes and disease states. This antibody provides a reliable tool for investigating the mechanisms underlying MMP15 function, ultimately leading to a better understanding of its potential as a target for therapeutic intervention.
Antibody Name:
MMP15 Antibody (PACO14711)
Antibody SKU:
PACO14711
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:1000-1:5000, WB:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
Fusion protein of human MMP15
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse heart tissue, Primary antibody: PACO14711(MMP15 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 90 seconds.
Background:
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.
Synonyms:
matrix metallopeptidase 15 (membrane-inserted)
UniProt Protein Function:
MMP15: Endopeptidase that degrades various components of the extracellular matrix. May activate progelatinase A. Belongs to the peptidase M10A family.
UniProt Protein Details:
Protein type:Membrane protein, integral; EC 3.4.24.-; Protease
Chromosomal Location of Human Ortholog: 16q13
Cellular Component: plasma membrane
Molecular Function:enzyme activator activity; protein binding; serine-type endopeptidase activity
Biological Process: collagen catabolic process; extracellular matrix disassembly; protein modification process
NCBI Summary:
This gene encodes a member of the peptidase M10 family and membrane-type subfamily of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Members of this subfamily contain a transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. The encoded preproprotein is proteolytically processed to generate the mature protease. This protein may play a role in cancer progression. [provided by RefSeq, Jan 2016]
