The MMP14 Polyclonal Antibody (CAB15691) is a vital tool for researchers studying matrix metalloproteinase 14 (MMP14), a key enzyme involved in matrix remodeling and cell migration processes. This antibody, produced in rabbits, exhibits high specificity and reactivity towards human samples, making it suitable for Western blot applications. By targeting the MMP14 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an essential tool for researchers in the fields of cell biology, cancer research, and tissue remodeling studies.
MMP14 is known for its role in facilitating tumor invasion and metastasis, making it a promising target for anti-cancer therapy research. Additionally, MMP14 plays a critical role in tissue remodeling and wound healing processes. Research into the activity and regulation of MMP14 is essential for understanding its involvement in various diseases, including cancer, fibrosis, and arthritis. The MMP14 Polyclonal Antibody provides a valuable tool for investigating the functions of MMP14 and its potential therapeutic implications in disease treatment.
Product Name:
MMP14/MT1-MMP Rabbit Polyclonal Antibody
SKU:
CAB15691
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 75-174 of human MMP14/MT1-MMP (NP_004986.1).
Cytoplasm, Melanosome, Membrane, Single-pass type I membrane protein.
Calculated MW:
66kDa
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Purification Method:
Affinity purification
Gene ID:
4323
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Immunofluorescence analysis of U2OS cells using MMP14/MT1-MMPantibody (CAB15691) at dilution of 1:100. Blue: DAPI for nuclear staining.
