MMP14/MT1-MMP Rabbit Polyclonal Antibody (CAB15691)
- SKU:
- CAB15691
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | MMP14/MT1-MMP Rabbit Polyclonal Antibody |
SKU: | CAB15691 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 75-174 of human MMP14/MT1-MMP (NP_004986.1). |
Sequence: | QVTG KADA DTMK AMRR PRCG VPDK FGAE IKAN VRRK RYAI QGLK WQHN EITF CIQN YTPK VGEY ATYE AIRK AFRV WESA TPLR FREV PYAY IREG HEKQ |
Tested Applications: | IF/ICC ELISA |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1; MMP14/MT1-MMP |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Melanosome, Membrane, Single-pass type I membrane protein. |
Calculated MW: | 66kDa |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Purification Method: | Affinity purification |
Gene ID: | 4323 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |