MMP14/MT1-MMP Rabbit Monoclonal Antibody (CAB0067)
- SKU:
- CAB0067
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | MMP14/MT1-MMP Rabbit Monoclonal Antibody |
SKU: | CAB0067 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MMP14/MMP14/MT1-MMP (P50281). |
Sequence: | GAEI KANV RRKR YAIQ GLKW QHNE ITFC IQNY TPKV GEYA TYEA IRKA FRVW ESAT PLRF REVP YAYI REGH EKQA DIMI FFAE GFHG DSTP FDGE GGFL A |
Tested Applications: | WB IHC-P FC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 FC, 1:100 - 1:500 IHC-P, 1:50 - 1:200 |
Synonyms: | MMP-14; MMP-X1; MT-MMP; MT1MMP; MTMMP1; WNCHRS; MT1-MMP; MT-MMP 1; MMP14/MT1-MMP |
Positive Sample: | HeLa,HepG2,Mouse lung,Mouse kidney,Mouse heart,Rat heart |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Melanosome, Membrane, Single-pass type I membrane protein |
Calculated MW: | 66kDa |
Observed MW: | 52kDa/60kDa |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
Purification Method: | Affinity purification |
Gene ID: | 4323 |
Clone Number: | ARC0211 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |