[KO Validated] MMP13 Rabbit Polyclonal Antibody (CAB16920)
- SKU:
- CAB16920
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | [KO Validated] MMP13 Rabbit Polyclonal Antibody |
SKU: | CAB16920 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 104-272 of human MMP13 (NP_002418.1). |
Sequence: | YNVF PRTL KWSK MNLT YRIV NYTP DMTH SEVE KAFK KAFK VWSD VTPL NFTR LHDG IADI MISF GIKE HGDF YPFD GPSG LLAH AFPP GPNY GGDA HFDD DETW TSSS KGYN LFLV AAHE FGHS LGLD HSKD PGAL MFPI YTYT GKSH FMLP DDDV QGIQ SLYG PGDE D |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | CLG3; MDST; MANDP1; MMP-13; 13 |
Positive Sample: | 293T,HeLa,MCF7,A-549 |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 54kDa |
Observed MW: | 70kDa/55kDa |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. Mutations in this gene are associated with metaphyseal anadysplasia. This gene is part of a cluster of MMP genes on chromosome 11.
Purification Method: | Affinity purification |
Gene ID: | 4322 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |