The MMP12 Rabbit Monoclonal Antibody (CAB3713) is a powerful tool for researchers studying MMP12, a member of the matrix metalloproteinase family known for its role in tissue remodeling and inflammatory processes. This antibody, produced in rabbits, has high specificity and sensitivity for human samples, making it ideal for applications such as Western blotting.MMP12 is implicated in various pathological conditions, including chronic obstructive pulmonary disease (COPD), asthma, and cardiovascular diseases. By targeting MMP12, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially develop new therapeutic strategies.
With its ability to detect and analyze MMP12 in different cell types, the MMP12 Rabbit Monoclonal Antibody is a valuable tool for studies in immunology, respiratory diseases, and cardiovascular research. Its reliable performance and reproducibility make it a key reagent for advancing our understanding of MMP12 biology and its implications in human health.
Product Name:
MMP12 Rabbit Monoclonal Antibody
SKU:
CAB3713
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 371-470 of human MMP12 (P39900).
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11.
Purification Method:
Affinity purification
Gene ID:
4321
Clone Number:
ARC0280
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MMP12 pAb (CAB3713) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
