Description
Product Name: | MMP-1 (H440) Polyclonal Antibody |
SKU: | CAB24436 |
Size: | 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 369-469 of human MMP1 (NP_002412.1). |
Sequence: | FPRT VKHI DAAL SEEN TGKT YFFV ANKY WRYD EYKR SMDP GYPK MIAH DFPG IGHK VDAV FMKD GFFY FFHG TRQY KFDP KTKR ILTL QKAN SWFN CRKN |
Tested Applications: | IF/ICC |
Recommended Dilution: | IF/ICC,1:50 - 1:200 |
Synonyms: | CLG; CLGN; MMP-1 (H440) |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 54kDa |
Observed MW: | Refer to figures |
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
Purification Method: | Affinity purification |
Gene ID: | 4312 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |