The Human CD10 Monoclonal Antibody (CB-CALLA, AGEL0294) offered by AssayGenie is a highly specific antibody designed for research applications involving CD10, a cell surface enzyme found in various human tissues. This monoclonal antibody, optimized for recognizing human CD10, is ideal for use in immunohistochemistry, flow cytometry, and other experimental techniques where precise detection of CD10 expression is crucial.CD10, also known as common acute lymphoblastic leukemia antigen (CALLA), is a marker commonly used in the diagnosis and classification of hematopoietic neoplasms, particularly lymphoid malignancies. Its expression pattern in normal and malignant tissues makes it a valuable target for cancer research and diagnostic purposes.
This monoclonal antibody enables specific and sensitive detection of CD10, providing researchers with a powerful tool for studying its role in normal physiology and disease pathology.With its high specificity and sensitivity for human CD10, the AGEL0294 monoclonal antibody from AssayGenie is a reliable reagent for investigating CD10 expression and function in various biological contexts. Whether studying normal tissue development, hematological disorders, or solid tumors, this antibody facilitates precise and accurate detection of CD10, contributing to a deeper understanding of its biological significance.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD10 is a 100 kD neutral endopeptidase and a member of the metalloprotease family. It is a type II transmembrane protein also known as common acute lymphoblastic leukemia antigen (CALLA), enkephalinase, and neprilysin. CD10 is expressed on B cell precursors, T cell precursors, and neutrophils. CD10 is involved in B cell development and has been shown to bind opioid enkephalins, bradykinin, angiotensins I and II, and other biologically active peptides.