The MMD2 Polyclonal Antibody (PACO37794) is a valuable tool for researchers studying the MMD2 protein, which is involved in lipid metabolism. This antibody, produced in rabbits, is highly specific to human samples and is ideal for use in Western blot applications. By binding to the MMD2 protein, this antibody allows for precise detection and analysis in a variety of cell types, making it a crucial tool for studies in lipid metabolism, diabetes, and other metabolic disorders.MMD2, also known as Malonyl-CoA Decarboxylase 2, plays a key role in the regulation of fatty acid metabolism by catalyzing the conversion of malonyl-CoA to acetyl-CoA, a process critical for energy production and lipid synthesis.
Dysregulation of MMD2 has been implicated in metabolic diseases such as diabetes, obesity, and cardiovascular disorders, making it a promising target for therapeutic interventions aimed at modulating lipid metabolism.By utilizing the MMD2 Polyclonal Antibody in their research, scientists can gain valuable insights into the functions and regulation of the MMD2 protein, ultimately advancing our understanding of lipid metabolism and its implications for human health. This antibody is a reliable tool for investigations into metabolic disorders and the development of novel therapeutic strategies targeting MMD2-related pathways.
Western blot. All lanes: MMD2 antibody at 3µg/ml. Lane 1: Mouse brain tissue. Lane 2: Mouse kidney tissue. Lane 3: U251 whole cell lysate. Lane 4: 293T whole cell lysate. Lane 5: Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 32, 29, 23 kDa. Observed band size: 23 kDa.
Immunofluorescent analysis of U251 cells using PACO37794 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human testis tissue using PACO37794 at dilution of 1:100.
Background:
perinuclear region of cytoplasm, protein kinase activity, positive regulation of neuron differentiation, positive regulation of protein kinase activity, positive regulation of Ras protein signal transduction, protein phosphorylation, regulation of protein localization
Synonyms:
Monocyte to macrophage differentiation factor 2 (Progestin and adipoQ receptor family member 10) (Progestin and adipoQ receptor family member X), MMD2, PAQR10
UniProt Protein Function:
MMD2: a member of the PAQR (progestin and adipoQ receptor) family. Members of this family are evolutionarily conserved with significant sequence identity to bacterial hemolysin-like proteins and are defined by a set of seven transmembrane domains. The protein encoded by this gene localizes to the Golgi apparatus to modulate Ras signaling. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 7p22.1Cellular Component: perinuclear region of cytoplasmMolecular Function: protein kinase activityBiological Process: positive regulation of neuron differentiation; positive regulation of protein kinase activity; positive regulation of Ras protein signal transduction; regulation of protein localization
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the PAQR (progestin and adipoQ receptor) family. Members of this family are evolutionarily conserved with significant sequence identity to bacterial hemolysin-like proteins and are defined by a set of seven transmembrane domains. The protein encoded by this gene localizes to the Golgi apparatus to modulate Ras signaling. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jun 2012]
