The MMADHC Polyclonal Antibody (CAB15820) is a valuable tool for researchers studying MMADHC, a protein involved in the metabolism of cobalamin (Vitamin B12) and the breakdown of amino acids. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to MMADHC, this antibody enables researchers to detect and analyze the protein in various cell types, making it ideal for studies in metabolic disorders and vitamin deficiency-related diseases.MMADHC plays a crucial role in the intracellular processing of Vitamin B12, which is essential for numerous biochemical pathways in the body, including DNA synthesis and nervous system function.
Mutations in the MMADHC gene have been linked to methylmalonic acidemia and homocystinuria, two rare inherited metabolic disorders that can lead to severe health complications if left untreated. By investigating the function and regulation of MMADHC, researchers can gain insights into the pathogenesis of these diseases and potentially identify new therapeutic targets for treatment.
Product Name:
MMADHC Rabbit Polyclonal Antibody
SKU:
CAB15820
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-296 of human MMADHC (NP_056517.1).
This gene encodes a mitochondrial protein that is involved in an early step of vitamin B12 metabolism. Vitamin B12 (cobalamin) is essential for normal development and survival in humans. Mutations in this gene cause methylmalonic aciduria and homocystinuria type cblD (MMADHC), a disorder of cobalamin metabolism that is characterized by decreased levels of the coenzymes adenosylcobalamin and methylcobalamin. Pseudogenes have been identified on chromosomes 11 and X.
Purification Method:
Affinity purification
Gene ID:
27249
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using MMADHC Rabbit pAb (CAB15820) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
