The MLXIPL Polyclonal Antibody (CAB7630) is a valuable tool for researchers investigating MLXIPL, a transcription factor involved in lipid metabolism and glucose homeostasis. This antibody, generated in rabbits, exhibits high specificity for human samples and has been validated for use in Western blotting applications. By binding to the MLXIPL protein, researchers can accurately detect and analyze its expression in various cell types, making it an ideal choice for studies focused on metabolic disorders and diabetes research.
MLXIPL, also known as carbohydrate-responsive element-binding protein (ChREBP), plays a crucial role in regulating genes involved in glucose and lipid metabolism. Its function in controlling metabolic pathways makes it a promising target for studies examining metabolic diseases such as diabetes and obesity. Understanding the role of MLXIPL in these processes is essential for developing targeted therapies aimed at managing metabolic disorders and improving overall health outcomes.
Product Name:
MLXIPL Rabbit Polyclonal Antibody
SKU:
CAB7630
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 17-175 of human MLXIPL (NP_116569.1).
This gene encodes a basic helix-loop-helix leucine zipper transcription factor of the Myc/Max/Mad superfamily. This protein forms a heterodimeric complex and binds and activates, in a glucose-dependent manner, carbohydrate response element (ChoRE) motifs in the promoters of triglyceride synthesis genes. The gene is deleted in Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51085
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MLXIPL antibody (CAB7630) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
