The MLNR Antibody (PAC018253) is a polyclonal antibody specifically designed for research involving MLNR, a G protein-coupled receptor known for its role in gastrointestinal function and smooth muscle contraction. This antibody, produced by Assay Genie, is raised in rabbits and is highly reactive with human samples, making it a reliable tool for immunohistochemistry and other molecular biology applications.MLNR, also known as the motilin receptor, plays a crucial role in regulating gastrointestinal motility and has been implicated in various digestive disorders. By targeting MLNR, researchers can gain insights into the molecular mechanisms underlying gastrointestinal function and potentially identify new therapeutic targets for conditions like gastroesophageal reflux disease (GERD) and irritable bowel syndrome (IBS).
The MLNR Antibody (PAC018253) allows for the detection and analysis of MLNR expression in a variety of tissues and cell types, making it an invaluable tool for studies in gastroenterology and pharmacology. By understanding the function and regulation of MLNR, researchers can pave the way for the development of novel treatments aimed at modulating gastrointestinal motility and alleviating symptoms associated with GI disorders.
Antibody Name:
MLNR Antibody (PACO18253)
Antibody SKU:
PACO18253
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human MLNR
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO18253(MLNR Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Motilin is a 22 amino acid, peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders.
Synonyms:
motilin receptor
UniProt Protein Function:
MLNR: Receptor for motilin. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCRChromosomal Location of Human Ortholog: 13q14-q21Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; growth hormone-releasing hormone receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; digestion
UniProt Protein Details:
NCBI Summary:
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
