The MLNR Polyclonal Antibody (PACO00876) is a vital tool for researchers studying the MLNR protein, also known as the motilin receptor. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the MLNR protein, this antibody allows for the detection and analysis of MLNR in various cell types, making it ideal for investigations in gastrointestinal physiology and pharmacology.The motilin receptor plays a crucial role in the regulation of gastrointestinal motility and emptying.
Its involvement in the modulation of smooth muscle contractions in the gastrointestinal tract makes it a key target for research into functional gastrointestinal disorders and potential therapeutic interventions. Understanding the function and regulation of the MLNR protein is essential for advancing knowledge in areas such as gastrointestinal health and drug development for gastrointestinal disorders.
Antibody Name:
MLNR Antibody
Antibody SKU:
PACO00876
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the C-terminal region of human GPR38.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
MLNR: Receptor for motilin. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCRChromosomal Location of Human Ortholog: 13q14-q21Cellular Component: integral to plasma membrane; plasma membraneMolecular Function: G-protein coupled receptor activity; growth hormone-releasing hormone receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; digestion
UniProt Protein Details:
NCBI Summary:
Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]
