The MLLT3-AF9 Monoclonal Antibody is a crucial tool for researchers studying the MLLT3-AF9 fusion protein, a significant driver of acute myeloid leukemia (AML). This antibody, produced using hybridoma technology, exhibits high specificity and sensitivity for detecting MLLT3-AF9 in human samples, making it an essential component in AML research.MLLT3-AF9, resulting from a chromosomal translocation, plays a pivotal role in leukemogenesis by promoting abnormal cell growth and inhibition of differentiation. Targeting this fusion protein has emerged as a promising therapeutic strategy in AML treatment.
The MLLT3-AF9 Monoclonal Antibody enables accurate detection and quantification of this protein, facilitating detailed investigation into its function and potential as a therapeutic target.Researchers in the field of oncology and hematology will greatly benefit from the exceptional performance of the MLLT3-AF9 Monoclonal Antibody in experimental techniques like immunoprecipitation and immunofluorescence. Its reliability and precision make it an indispensable resource for unraveling the mechanisms underlying AML pathogenesis and developing novel treatment approaches.
Product Name:
MLLT3/AF9 Monoclonal Antibody
SKU:
CAB22072
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human MLLT3/AF9 (NP_004520.2).
Enables chromatin binding activity and lysine-acetylated histone binding activity. Involved in several processes, including hematopoietic stem cell differentiation; positive regulation of transcription, DNA-templated; and regulation of stem cell division. Acts upstream of or within negative regulation of canonical Wnt signaling pathway and positive regulation of Wnt signaling pathway, planar cell polarity pathway. Located in cytosol and nucleoplasm. Part of transcription elongation factor complex.
Purification Method:
Affinity purification
Gene ID:
4300
Clone Number:
ARC51958
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MLLT3/AF9 antibody (CAB22072) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
