MLKL Polyclonal Antibody (CAB23063)
- SKU:
- CAB23063
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Frequently bought together:
Description
Product Name: | MLKL Polyclonal Antibody |
SKU: | CAB23063 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 179-471 of human MLKL. (NP_689862.1). |
Sequence: | YLPP KCMQ EIPQ EQIK EIKK EQLS GSPW ILLR ENEV STLY KGEY HRAP VAIK VFKK LQAG SIAI VRQT FNKE IKTM KKFE SPNI LRIF GICI DETV TPPQ FSIV MEYC ELGT LREL LDRE KDLT LGKR MVLV LGAA RGLY RLHH SEAP ELHG KIRS SNFL VTQG YQVK LAGF ELRK TQTS MSLG TTRE KTDR VKST AYLS PQEL EDVF YQYD VKSE IYSF GIVL WEIA TGDI PFQG CNSE KIRK LVAV KRQQ EPLG EDCP SELR EIID ECRA HDPS VRPS VDEI LKKL STFS K |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | hMLKL; KL |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm. |
Calculated MW: | 54kDa |
Observed MW: | 54kDa |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.
Purification Method: | Affinity purification |
Gene ID: | 197259 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |