The MLK4 Polyclonal Antibody (PACO21877) is an essential tool for researchers investigating the role of MLK4, a key protein kinase involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for effective use in Western blot applications. By specifically binding to the MLK4 protein, this antibody enables precise detection and analysis in a variety of cell types, making it well-suited for studies in both immunology and cancer research.MLK4, also known as mixed lineage kinase 4, plays a crucial role in signal transduction pathways that govern cell proliferation, differentiation, and apoptosis.
Its implications in cell cycle regulation and tumorigenesis make it a promising target for investigating cancer progression and potential therapeutic interventions. Understanding the function of MLK4 is essential for developing strategies to target this kinase in cancer treatment and other diseases where dysregulation of signaling pathways occurs.Overall, the MLK4 Polyclonal Antibody is a valuable tool for researchers seeking to deepen their understanding of cellular signaling mechanisms and the potential implications for disease development and treatment.
Antibody Name:
MLK4 Antibody (PACO21877)
Antibody SKU:
PACO21877
Size:
100ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:3000
Species Reactivity:
Human
Immunogen:
Synthesized peptide derived from internal of human MAP3KL4.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen Gregory S.G., Nature 441:315-321(2006).
Clonality:
Polyclonal
Conjugate:
Non-conjugated
Western blot analysis of extracts from HT-29 cells, using MAP3KL4 antibody.
MLK4: Activates the JUN N-terminal pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Protein kinase, TKL; Kinase, protein; Motility/polarity/chemotaxis; EC 2.7.11.25; Protein kinase, Ser/Thr (non-receptor); TKL group; MLK family; MLK subfamily
Chromosomal Location of Human Ortholog: 1q42
Molecular Function:protein binding; protein homodimerization activity
Biological Process: activation of JNK activity; protein amino acid autophosphorylation; protein amino acid phosphorylation
