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MLH3 Rabbit Polyclonal Antibody (CAB7796)

SKU:
CAB7796
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-MLH3 Antibody CAB7796
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-MLH3 Antibody CAB7796
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:MLH3 Rabbit Polyclonal Antibody
SKU:CAB7796
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1190-1389 of human MLH3 (NP_055196.2).
Sequence:QVLQ QVDN KFIA CLMS TKTE ENGE ADSY EKQQ AQGS GRKK LLSS TLIP PLEI TVTE EQRR LLWC YHKN LEDL GLEF VFPD TSDS LVLV GKVP LCFV EREA NELR RGRS TVTK SIVE EFIR EQLE LLQT TGGI QGTL PLTV QKVL ASQA CHGA IKFN DGLS LQES CRLI EALS SCQL PFQC AHGR PSML PLAD IDHL EQEK
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:HNPCC7; MLH3
Positive Sample:HCT116
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:164kDa
Observed MW:164kDa

This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The protein encoded by this gene functions as a heterodimer with other family members. Somatic mutations in this gene frequently occur in tumors exhibiting microsatellite instability, and germline mutations have been linked to hereditary nonpolyposis colorectal cancer type 7 (HNPCC7). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Purification Method:Affinity purification
Gene ID:27030
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of HCT116, using MLH3 Rabbit pAb (CAB7796) at 1:3500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.

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