MLH1 Rabbit Monoclonal Antibody (CAB4858)
- SKU:
- CAB4858
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- COCA2
- FCC2
- HNPCC
- HNPCC2
- hMLH1
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | MLH1 Rabbit Monoclonal Antibody |
SKU: | CAB4858 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 350-450 of human MLH1 (NP_000240.1). |
Sequence: | PGLA GPSG EMVK STTS LTSS STSG SSDK VYAH QMVR TDSR EQKL DAFL QPLS KPLS SQPQ AIVT EDKT DISS GRAR QQDE EMLE LPAP AEVA AKNQ SLEG D |
Tested Applications: | IHC-P |
Recommended Dilution: | IHC-P,1:50 - 1:200 |
Synonyms: | FCC2; COCA2; HNPCC; MLH-1; hMLH1; HNPCC2; LYNCH2; MMRCS1; H1 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus |
Calculated MW: | 85kDa |
The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC).
Purification Method: | Affinity purification |
Gene ID: | 4292 |
Clone Number: | ARC53543(鄂汉械备20230535号) |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |