The MKRN3 Polyclonal Antibody (CAB16073) is a valuable tool for researchers studying the MKRN3 protein, which is implicated in various physiological processes such as puberty initiation and reproductive function. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it suitable for use in Western blot applications.MKRN3 is a crucial player in the regulation of puberty onset, as it acts as a negative regulator of the hypothalamic-pituitary-gonadal axis. Dysregulation of MKRN3 has been linked to central precocious puberty, a condition characterized by early onset of puberty.
Therefore, studying the expression and function of MKRN3 is essential for understanding the mechanisms underlying this complex biological process.With its ability to bind specifically to the MKRN3 protein, this polyclonal antibody enables researchers to detect and analyze MKRN3 expression in various cell types, providing valuable insights into its role in puberty initiation and reproductive development. This antibody is a valuable tool for studies focused on endocrinology, reproductive biology, and developmental biology.
Product Name:
MKRN3 Rabbit Polyclonal Antibody
SKU:
CAB16073
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human MKRN3 (NP_005655.1).
The protein encoded by this gene contains a RING (C3HC4) zinc finger motif and several C3H zinc finger motifs. This gene is intronless and imprinted, with expression only from the paternal allele. Disruption of the imprinting at this locus may contribute to Prader-Willi syndrome. An antisense RNA of unknown function has been found overlapping this gene.
Purification Method:
Affinity purification
Gene ID:
7681
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse kidney, using MKRN3 Rabbit pAb (CAB16073) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
