The MKP1 Polyclonal Antibody (CAB24667) is a valuable tool for research involving the mitogen-activated protein kinase phosphatase 1 (MKP1) protein. MKP1 is a key regulator of cellular signaling pathways involved in cell growth, proliferation, and differentiation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.By binding to the MKP1 protein, this antibody enables precise detection and analysis of MKP1 expression in various cell types. Its high reactivity and specificity make it an ideal choice for studies in cell signaling, cancer biology, and drug development.
Understanding the regulation of MKP1 activity is essential for unraveling the complexities of cellular signaling pathways and developing targeted therapies for diseases like cancer and inflammatory disorders.Overall, the MKP1 Polyclonal Antibody (CAB24667) offers researchers a reliable tool for investigating the role of MKP1 in cellular processes and disease pathogenesis, providing valuable insights that may pave the way for new therapeutic interventions.
Product Name:
MKP1 Polyclonal Antibody
SKU:
CAB24667
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 267-367 of human MKP1 (NP_004408.1).
The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy.
Purification Method:
Affinity purification
Gene ID:
1843
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MKP1 Rabbit pAb (CAB24667) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Negative control (NC):THP-1Exposure time: 3s.
