The MKP1 Polyclonal Antibody (CAB23261) is an essential tool for researchers studying the MAP kinase phosphatase 1 (MKP1) protein. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting.MKP1 is a key regulator of MAP kinase signaling pathways, playing a critical role in the control of cellular responses to extracellular stimuli. Dysregulation of MKP1 has been implicated in various diseases, making it a valuable target for research in cancer, inflammation, and other pathologies.
By specifically binding to the MKP1 protein, this antibody allows for the detection and analysis of MKP1 in a range of cell types, providing valuable insights into its function and potential as a therapeutic target. Researchers in the fields of cell signaling, oncology, and immunology will find this antibody indispensable for their studies on MKP1 and its role in disease pathogenesis.
Product Name:
MKP1 Polyclonal Antibody
SKU:
CAB23261
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant protein of mouse MKP1.
Tested Applications:
WBELISA
Recommended Dilution:
WB,1:1000 - 1:5000
Synonyms:
erp; MKP1; mkp-1; 3CH134; Ptpn16
Positive Sample:
HeLa,HL-60,Mouse lung,Rat lung,Rat testis
Conjugate:
Unconjugated
Calculated MW:
39kDa
Observed MW:
40kDa
Enables mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of MAPK cascade; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1).
Purification Method:
Affinity purification
Gene ID:
19252
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MKP1 Rabbit pAb (CAB23261) at 1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 2s.
