The MKL1 Polyclonal Antibody (CAB8504) is a powerful tool for researchers studying MKL1, a transcription coactivator involved in gene expression regulation. This antibody is produced in rabbits and specifically recognizes MKL1 in human samples, making it an excellent choice for Western blot applications. By targeting the MKL1 protein, researchers can accurately detect and analyze its expression levels in various cell types, providing valuable insights into its role in cellular function and gene regulation.MKL1, also known as MRTF-A, is a key player in cellular processes such as migration, adhesion, and differentiation.
Its involvement in these processes links it to a variety of diseases, including cancer and cardiovascular disorders. By studying MKL1 with this antibody, researchers can uncover important information about its function and potential therapeutic implications in these disease contexts. This antibody is an essential tool for investigating the mechanisms of MKL1 and its impact on cellular pathways, offering new opportunities for targeted research in molecular biology and disease therapeutics.
Product Name:
MKL1 Rabbit Polyclonal Antibody
SKU:
CAB8504
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human MKL1 (NP_065882.1).
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
57591
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using MKL1 Rabbit pAb (CAB8504) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
