MKL1 Rabbit Polyclonal Antibody (CAB14212)
- SKU:
- CAB14212
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | MKL1 Rabbit Polyclonal Antibody |
SKU: | CAB14212 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human MKL1 (NP_065882.1). |
Sequence: | MPPL KSPA AFHE QRRS LERA RTED YLKR KIRS RPER SELV RMHI LEET SAEP SLQA KQLK LKRA RLAD DLNE KIAQ RPGP MELV EKNI LPVE SSLK EAII VGQV NYPK VADS SSFD EDSS DALS PEQP ASHE SQGS VPSP LEAR VSEP LLSA TSAS PTQV VSQL PMGR DSRE MLFL AEQP PLPP PPLL PPSL TNGT TIPT AKST PTLI KQSQ PKSA SEKS QRSK KAKE LKPK VKKL KYHQ YIPP DQKQ DRGA PPMD SSYA KILQ QQQL FLQL QILN QQQQ |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:100 |
Synonyms: | MAL; MKL; BSAC; MKL1; MRTF-A |
Positive Sample: | TE-1,HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 99kDa |
Observed MW: | 150kDa |
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 57591 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |