The MKL1 Polyclonal Antibody (CAB14212) is a valuable tool for researchers studying MKL1, a key regulatory protein involved in gene expression and cell migration. This antibody is raised in rabbits and has high specificity for human samples, making it suitable for use in Western blot applications. By binding to the MKL1 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it ideal for investigations in cell biology and cancer research.MKL1, also known as MRTFA, plays a crucial role in controlling the expression of genes involved in cell proliferation, differentiation, and migration.
Its involvement in these processes makes it a promising target for studying various diseases, including cancer and cardiovascular disorders. By understanding the function of MKL1, researchers can gain insights into the mechanisms underlying disease progression and potentially develop targeted therapies to combat these conditions.Overall, the MKL1 Polyclonal Antibody (CAB14212) offers researchers a reliable tool for studying the role of MKL1 in cellular processes and disease pathogenesis, furthering our understanding of the molecular mechanisms driving these complex biological processes.
Product Name:
MKL1 Rabbit Polyclonal Antibody
SKU:
CAB14212
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human MKL1 (NP_065882.1).
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
57591
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using MKL1 antibody (CAB14212) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
