The MFN2 Polyclonal Antibody (CAB12771) is a valuable tool for researchers studying Mitofusin-2 (MFN2), a protein involved in mitochondrial fusion and maintenance. This antibody, generated in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to MFN2, this antibody allows for the detection and analysis of MFN2 protein levels in a variety of cell types.MFN2 is a key player in mitochondrial dynamics, playing a crucial role in maintaining mitochondrial function and regulating processes such as apoptosis and metabolism. Dysregulation of MFN2 has been implicated in a variety of diseases, including neurodegenerative disorders and metabolic syndromes.
Studying the function and expression of MFN2 is essential for understanding the role of mitochondria in health and disease.With its specificity and reliability, the MFN2 Polyclonal Antibody is an indispensable tool for researchers investigating the intricate mechanisms of mitochondrial dynamics and their impact on cellular health. By enabling the accurate detection and quantification of MFN2 protein levels, this antibody contributes to the advancement of research in fields such as cell biology, neurology, and metabolic disorders.
Product Name:
Mitofusin 2 Rabbit Polyclonal Antibody
SKU:
CAB12771
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 70-260 of human Mitofusin 2 (NP_055689.1).
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified.
Purification Method:
Affinity purification
Gene ID:
9927
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat brain, using Mitofusin 2 Rabbit pAb (CAB12771) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
