The MITF Rabbit Monoclonal Antibody is a highly specific tool for researchers studying the MITF protein, a transcription factor essential for melanocyte development and function. This antibody, produced in rabbit cells, demonstrates high affinity and specificity for MITF in human samples, making it ideal for use in various immunohistochemistry and Western blotting applications.MITF, also known as microphthalmia-associated transcription factor, is a key regulator of melanocyte differentiation, melanin production, and cell survival.
Dysregulation of MITF has been implicated in various melanoma subtypes and other cancers, making it a crucial target for cancer research and drug development. By targeting MITF with this antibody, researchers can gain insights into the molecular mechanisms underlying melanoma progression and potentially discover new therapeutic strategies targeting MITF signaling pathways.
Product Name:
MITF Rabbit Monoclonal Antibody
SKU:
CAB11649
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 387-509 of human MITF (O75030).
The protein encoded by this gene is a transcription factor that contains both basic helix-loop-helix and leucine zipper structural features. The encoded protein regulates melanocyte development and is responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the this gene cause auditory-pigmentary syndromes, such as Waardenburg syndrome type 2 and Tietz syndrome.
Purification Method:
Affinity purification
Gene ID:
4286
Clone Number:
ARC0660
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Confocal imaging of HeLa cells using MITF Rabbit mAb (A11649,dilution 1:100)(Red). The cells were counterstained with α-Tubulin Mouse mAb (AC012,dilution 1:400) (Green). DAPI was used for nuclear staining (blue). Objective: 60x.
