The MiPOL1 Polyclonal Antibody (PACO10499) is an essential tool for researchers studying MiPOL1, a protein involved in DNA repair and maintenance processes. This antibody, produced in rabbits, exhibits high specificity and reactivity with human samples, making it ideal for use in Western blot applications.MiPOL1 plays a crucial role in maintaining genomic stability and preventing the accumulation of DNA damage, making it a key player in cell survival and genomic integrity. Dysregulation of MiPOL1 has been linked to various diseases, including cancer and neurodegenerative disorders, highlighting the importance of understanding its function and regulation.
By using the MiPOL1 Polyclonal Antibody, researchers can effectively detect and analyze MiPOL1 protein levels in different cell types, providing valuable insights into its role in DNA repair mechanisms and its potential as a therapeutic target. This antibody is a valuable tool for studies in molecular biology, cancer research, and other fields aiming to unravel the complexities of DNA maintenance and repair pathways.
MIPOL1: A chromosomal aberration involving MIPOL1 is found in a patient with mirror-image polydactyly of hands and feet without other anomalies (MIP). Translocation t(2;14)(p23.3;q13). MIP is a very rare congenital anomaly characterized by mirror- image duplication of digits. MIP is occasionally associated with dimelia of the ulna and fibula, tibial and/or fibular hypoplasia, nasal abnormality and other malformations. Most MIP cases are sporadic, but very rare parent-child transmissions observed in familial cases suggest an autosomal mode of inheritance. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 14q13.3Cellular Component: nucleusDisease: Laurin-sandrow Syndrome
UniProt Protein Details:
NCBI Summary:
This gene encodes a coiled-coil domain-containing protein. The encoded protein may function as a tumor suppressor. A translocation that results in truncation of the protein encoded by this locus has been associated with mirror-image polydactyly, also known as Laurin-Sandrow Syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2010]
