MINK1 Antibody (PACO21895)
- SKU:
- PACO21895
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Antibody Name: | MINK1 Antibody (PACO21895) |
Antibody SKU: | PACO21895 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human, Mouse |
Immunogen: | Synthesized peptide derived from internal of human MAP4K6. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from COLO cells, using MAP4K6 antibody. |
Background: | Serine/threonine kinase which acts as a negative regulator of Ras-related Rap2-mediated signal transduction to control neuronal structure and AMPA receptor trafficking. Required for normal synaptic density, dendrite complexity, as well as surface AMPA receptor expression in hippocampal neurons. Can activate the JNK and MAPK14/p38 pathways and mediates stimulation of the stress-activated protein kinase MAPK14/p38 MAPK downstream of the Raf/ERK pathway. Phosphorylates: TANC1 upon stimulation by RAP2A, MBP and SMAD1. Has an essential function in negative selection of thymocytes, perhaps by coupling NCK1 to activation of JNK1. Isoform 4 can activate the JNK pathway. Involved in the regulation of actin cytoskeleton reorganization, cell-matrix adhesion, cell-cell adhesion and cell migration. Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). |
Synonyms: | EC 2.7.11.1; Mitogen-activated protein kinase kinase kinase kinase 6; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6 |
UniProt Protein Function: | MINK: a protein kinase of the STE20 family. Studies of the mouse ortholog indicate increased expression during postnatal mouse cerebral development. Activates JNK and the p38 pathways. Three splicing isoforms have been described. |
UniProt Protein Details: | Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MSN subfamily Chromosomal Location of Human Ortholog: 17p13.2 Cellular Component: axon; cell junction; cytoplasm; cytosol; dendrite; Golgi apparatus; postsynaptic density; postsynaptic membrane Molecular Function:ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity Biological Process: actin cytoskeleton reorganization; dendrite morphogenesis; JNK cascade; microvillus biogenesis; multicellular organismal development; negative thymic T cell selection; neurite morphogenesis; positive regulation of JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell migration; regulation of cell-cell adhesion; regulation of cell-matrix adhesion; regulation of mitotic cell cycle; response to stress; synaptic transmission |
NCBI Summary: | This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016] |
UniProt Code: | Q8N4C8 |
NCBI GenInfo Identifier: | 296437370 |
NCBI Gene ID: | 50488 |
NCBI Accession: | Q8N4C8.2 |
UniProt Secondary Accession: | Q8N4C8,Q5U8Z0, Q9P1X1, Q9P2R8, D3DTK3, D3DTK4, |
UniProt Related Accession: | Q8N4C8 |
Molecular Weight: | 143,637 Da |
NCBI Full Name: | Misshapen-like kinase 1 |
NCBI Synonym Full Names: | misshapen like kinase 1 |
NCBI Official Symbol: | MINK1Â Â |
NCBI Official Synonym Symbols: | B55; ZC3; MINK; YSK2; MAP4K6Â Â |
NCBI Protein Information: | misshapen-like kinase 1 |
UniProt Protein Name: | Misshapen-like kinase 1 |
UniProt Synonym Protein Names: | GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6 |
Protein Family: | Misshapen-like kinase |
UniProt Gene Name: | MINK1Â Â |
UniProt Entry Name: | MINK1_HUMAN |
Antibodies | ELISA Kits |
MINK1 Antibody (PACO01065) | MAP4K6 Colorimetric Cell-Based ELISA |
MINK1 Antibody (PACO10496) |
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