null

MINK1 Antibody (PACO10496)

(No reviews yet) Write a Review
SKU:
PACO10496
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459

Description

system_update_altDatasheetsystem_update_altMSDS

MINK1 Antibody (PACO10496)

The MINK1 Polyclonal Antibody (PAC010496) is a valuable tool for researchers studying the MINK1 protein, a kinase involved in cellular signaling pathways. This antibody, derived from rabbit immunizations, exhibits high reactivity with human samples and is optimized for Western blot applications. By specifically binding to the MINK1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for investigations in cell signaling, molecular biology, and cancer research.

MINK1, also known as misshapen-like kinase 1, plays a crucial role in regulating cell growth, proliferation, and migration through its involvement in various signaling cascades. Its significance in cellular processes makes it a valuable target for research into cancer, cardiovascular diseases, and developmental disorders. Understanding the function of MINK1 is essential for uncovering its role in disease progression and identifying potential therapeutic targets for intervention.

Antibody Name:MINK1 Antibody (PACO10496)
Antibody SKU:PACO10496
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:
Species Reactivity:Human, Mouse, Rat
Immunogen:Human MINK1
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:misshapen-like kinase 1 (zebrafish);MINK1;B55;MAP4K6;MGC21111;MINK;YSK2;ZC3;hMINK;hMINKβ ;
UniProt Protein Function:MINK: a protein kinase of the STE20 family. Studies of the mouse ortholog indicate increased expression during postnatal mouse cerebral development. Activates JNK and the p38 pathways. Three splicing isoforms have been described.
UniProt Protein Details:

Protein type:EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; MSN subfamily

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: axon; cell junction; cytoplasm; cytosol; dendrite; Golgi apparatus; postsynaptic density; postsynaptic membrane

Molecular Function:ATP binding; MAP kinase kinase kinase kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: actin cytoskeleton reorganization; dendrite morphogenesis; JNK cascade; microvillus biogenesis; multicellular organismal development; negative thymic T cell selection; neurite morphogenesis; positive regulation of JNK cascade; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of apoptosis; regulation of cell migration; regulation of cell-cell adhesion; regulation of cell-matrix adhesion; regulation of mitotic cell cycle; response to stress; synaptic transmission

NCBI Summary:This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]
UniProt Code:Q8N4C8
NCBI GenInfo Identifier:296437370
NCBI Gene ID:50488
NCBI Accession:Q8N4C8.2
UniProt Secondary Accession:Q8N4C8,Q5U8Z0, Q9P1X1, Q9P2R8, D3DTK3, D3DTK4,
UniProt Related Accession:Q8N4C8
Molecular Weight:143,637 Da
NCBI Full Name:Misshapen-like kinase 1
NCBI Synonym Full Names:misshapen like kinase 1
NCBI Official Symbol:MINK1  
NCBI Official Synonym Symbols:B55; ZC3; MINK; YSK2; MAP4K6  
NCBI Protein Information:misshapen-like kinase 1
UniProt Protein Name:Misshapen-like kinase 1
UniProt Synonym Protein Names:GCK family kinase MiNK; MAPK/ERK kinase kinase kinase 6; MEK kinase kinase 6; MEKKK 6; Misshapen/NIK-related kinase; Mitogen-activated protein kinase kinase kinase kinase 6
Protein Family:Misshapen-like kinase
UniProt Gene Name:MINK1  
UniProt Entry Name:MINK1_HUMAN

0 Reviews

View AllClose

Related Products