The MIF4GD Monoclonal Antibody (PACO28242) is a valuable tool for researchers studying MIF4GD, a protein involved in RNA processing and translation regulation. This monoclonal antibody, produced using state-of-the-art techniques, offers high specificity and sensitivity in detecting MIF4GD in a variety of samples, including human tissues and cell lines. Its versatility in applications such as immunofluorescence, immunoprecipitation, and flow cytometry makes it an essential asset for studies in molecular biology and cancer research.MIF4GD is known to interact with various proteins involved in mRNA translation and ribosome assembly, suggesting its importance in cellular processes essential for cell growth and proliferation.
Dysfunction of MIF4GD has been linked to abnormalities in mRNA splicing and protein synthesis, making it a potential target for therapeutic interventions in diseases like cancer and developmental disorders. By utilizing the MIF4GD Monoclonal Antibody, researchers can gain valuable insights into the mechanisms underlying these pathologies and develop targeted approaches for treatment.
Antibody Name:
MIF4GD Antibody (PACO28242)
Antibody SKU:
PACO28242
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human MIF4G domain-containing protein (1-133AA)
Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation.
Synonyms:
MIF4G domain-containing protein (SLBP-interacting protein 1) (hSLIP1), MIF4GD, SLIP1
UniProt Protein Function:
MIF4GD: Functions in replication-dependent translation of histone mRNAs which differ from other eukaryotic mRNAs in that they do not end with a poly-A tail but a stem-loop. May participate in circularizing those mRNAs specifically enhancing their translation. Belongs to the MIF4GD family. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 17q25.1Cellular Component: cytoplasm; nucleolusMolecular Function: protein C-terminus binding; protein binding; RNA bindingBiological Process: regulation of translation
UniProt Protein Details:
NCBI Summary:
This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
