The MICU1 Polyclonal Antibody (CAB21948) is a valuable tool for researchers studying MICU1, a key regulator of mitochondrial calcium uptake. This antibody, generated in rabbits, exhibits high reactivity towards human samples and is validated for use in Western blot applications. By binding specifically to the MICU1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for investigations in areas such as mitochondrial function and calcium signaling.MICU1 is essential for maintaining proper mitochondrial calcium levels, which play a critical role in various cellular processes, including energy production and cell death pathways.
Dysregulation of MICU1 has been linked to mitochondrial dysfunction and diseases such as neurodegenerative disorders and metabolic syndromes. Therefore, studying the role of MICU1 using this antibody is crucial for gaining insight into the mechanisms underlying these conditions and for identifying potential therapeutic targets.
Product Name:
MICU1 Polyclonal Antibody
SKU:
CAB21948
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 105-255 of human MICU1 (NP_001182447.1).
This gene encodes an essential regulator of mitochondrial Ca2+ uptake under basal conditions. The encoded protein interacts with the mitochondrial calcium uniporter, a mitochondrial inner membrane Ca2+ channel, and is essential in preventing mitochondrial Ca2+ overload, which can cause excessive production of reactive oxygen species and cell stress. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
10367
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using MICU1 antibody (CAB21948) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
